Preparation and Observation of Dissolution Characteristics of Ganciclovir Dispersible Tablets in Vitro
- VernacularTitle:更昔洛韦分散片的研制及体外溶出特性
- Author:
Wei WU
- Publication Type:Journal Article
- Keywords:
Ganciclovir;
Dispersible tablet;
Orthogonal test;
Dissolution
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare ganciclovir dispersible tablet and to observe its dissolution property in vitro.METHODS:The dosage of microcrystalline cellulose and crospolyvinylpyrrolidone in the formula were optimized by orthogonal test;The content of ganciclovir was determined by UV spectrophotometry method;Dissolution rates were compared among ganciclovir dispersible tablet,Ganciclovir common tablet and Ganciclovir capsule.RESULTS:The optimized formula dosage of microcrystalline cellulose and crospolyvinylpyrrolidone were40%and10%respectively;The linear concentration range for ganciclovir was2～20?g/ml(r=0.9999,n=6);The average recovery was(100.21?0.38)%;The mean values of intraday and the inter-day precision were0.22%and0.32%respectively;The ganciclovir dispersible tablet could completely disinte-grated within30s,T 50 was(0.03?0.001)min and T d was(0.18?0.006)min,which were all lower than those of the common tablet and capsule(P
