Study on Pharmacokinetics and Relative Bioavailability of Racemic Benzeneacetic Acid of Chirality Sus-tained Release Tablet in Human Body
- VernacularTitle:外消旋化布芬洛辛缓释片人体药动学及生物利用度研究
- Author:
Wenlong FENG
- Publication Type:Journal Article
- Keywords:
Racemic benzeneacetic acid of chirality sustained release tablet;
Multidoses;
Pharmacokinetics;
RP-HPLC;
Bioavailability
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVES:To study the pharmacokinetics of racemic benzeneacetic acid of chirality(RBAC)sustained re-lease tablet in human body of healthy volunteers,and to evaluate the bioequiavailability of RBAC and benzeneacetic acid of chirality(BAC)sustained release tablet.METHODS:18healthy volunteers studies were administered with multidoses of RBAC or BAC by randomized crossover and own control,the plasma concentrations of RBAC and BAC were determined by RP-HPLC,the pharmacokinetic parameters were calculated and ANOVA and two&one side t tests were carried out as well.RESULTS:The pharmacokinetic parameters of RBAC and BAC were respectively as follows:t 1/2 were(8.14?1.95)h and(8.81?2.27)h;t max were(3.44?0.62)h and(3.44?0.70)h;C ss max were(3.69?0.50)mg/L and(3.68?0.76)mg/L,AUC 0～t were(23.49?2.53)(mg?h)/L and(22.48?2.59)(mg?h)/L;DF were(138.21%?23.10)%and(134.53%?28.14)%;C ss were(1.96?0.21)mg/L and(1.85?0.22)mg/L;The relative bioavailability of RBAC to BAC was(102.45?8.07)%.CON-CLUSION:RBAC and BAC were bioequivalent.
