Observation of Pharmacodynamics in Patients with Continuous Infusion of Domestic Atracurium under Total Intravenous Anesthesia
- VernacularTitle:全凭静脉麻醉下持续输注国产阿曲库铵的药效学观察
- Author:
Wei ZOU
;
Rui WANG
- Publication Type:Journal Article
- Keywords:
Domestic atracurium;
Continuous infusion;
Total intravenous anesthesia;
Pharmacodynamics
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the feasibility and average infusion velocity of domestic atracurium by continuous in-fusion and to determine and validate its clinical valence.METHODS:80patients undergoing selective operation were treated with domestic atracurium0.5mg/kg to facilitate intubation under the flaccidity monitoring(TOF),the continuous infusion velocity was regulated during operation to keep the level of T 1 at1%～10%of the control value,the infusion was stopped20min before the termination of operation.RESULTS:The average infusion rate was(5.1?0.4)(?g?kg)/min,the drug effect starting time and duration of action of initial dose were(203?47)s and(41.5?4.5)min respectively;Significant correlations were found between the initial time of T 1 and PTC during the TOF reaction-free period and between TR value and DBS value at extubation time(P
