Determination of Two Constituents in Compound Streptomycin Cream
- VernacularTitle:紫外分光光度法测定复方链霉素软膏中2组分的含量
- Author:
Guiru LI
;
Huiyi LU
- Publication Type:Journal Article
- Keywords:
UV spectrophotometry;
Maltol-ammonium ferric sulfate colourimetry;
Streptomycin sulfate;
Sulfonamide;
Content determination
- From:
China Pharmacy
2001;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To determine streptomycin sulfate and sulfonamide in compound streptomycin cream by UV spectrophotometry.METHODS:The maltol-ammonium ferric sulfate colourimetry was adopted in which the ammonium ferric sulfate was taken as the developer,the absorbability of streptomycin sulfate was determined with the wavelength at521nm;The absorbability of sulfonamide was determined at a wavelength of251nm with0.1%mol/L NaOH taken as the sol-vent.RESULTS:The linear ranges of streptomycin sulfate and sulfonamide were200～950?g/ml(r=0.9994)and1.464～7.784?g/ml(r=0.9998)respectively;Their respective average recovery were99.1%(RSD=1.90%)and99.7%(RSD=1.60%).CONCLUSION:The method can be used as the quality control for compound streptomycin cream.
