The Effect of Fas and FasL Abnormal Expression on Immune Escape Mechanism of Renal Cell Carcinoma
- VernacularTitle:肾癌Fas和FasL蛋白表达异常对其免疫逃避机制的影响
- Author:
Fujin JIANG
;
Qijun ZHOU
;
Jiajun JIANG
- Publication Type:Journal Article
- Keywords:
Fas;
FasL;
apoptosis;
immune escape;
RCC
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Fas and FasL abnormal expression on immune escape mechanism of renal cell carcinoma(RCC). Methods The expression of Fas and FasL was detected in 44 cases of RCC and 10 cases of normal kidney tissue by immunohistochemical method. Tumor infiltrating T lymphocyte's apoptosis in 44 cases of RCC was examined by TUNEL assay. FCM was used to detect the expression of Fas and FasL as well as apoptosis in RCC cell line 786-0. In addition, the apoptosis of Jurkat T cell with Fas exprssion was also analysed with FCM. Results Fas expression rate (22.8%) in RCC was significantly lower than that (53.8%) in normal kidney tissue(P
