Expression and Clinical Significance of SKP2 and P27~(KIP1) Proteins in Human Gastric Cacinoma
- VernacularTitle:SKP2、P27~(KIP1)蛋白表达与胃癌的临床关系
- Author:
Huizeng LV
;
Xiaofeng ZHU
;
Xiutian ZHOU
- Publication Type:Journal Article
- Keywords:
Gastric carcinoma;
P27~ KIP1;
SKP2;
Ubiquitin-proteasome pathway
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of P27~ KIP1 and S-phase kinase-associated protein 2 (SKP2) expression in human gastric carcinoma. Methods The expression of P27~ KIP1 and SKP2 was determined by SP immunohistochemical method in 69 specimens of gastric carcinoma. Results The positive rates of P27~ KIP1 and SKP2 expression were 46.38% and 33.33%, respectively. The positive rate of P27~ KIP1 expression in gastric carcinoma decreased with the poor differentiation,deep invasion and progression of pathological grade (P0.05). There was a negative correlation between the P27~ KIP1 and SKP2 expression(P
