The Expression of hMLH_1, hMSH_2 in Hepatocellular Carcinoma and Its Clinical Significance
- VernacularTitle:hMLH_1、hMSH_2在原发性肝癌中的表达及其临床意义
- Author:
Gang LIANG
;
Dewu ZHONG
;
Zhulin YANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Mismatch repair gene;
Immunohistochemistry
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of hMLH1, hMSH2 and their association with clinico-pathological characteristics in hepatocellular carcinoma(HCC). Methods The expression of hMLH1 and hMSH2 in 37 HCC tissues was detected by SABC immunohistochemistry. Results The positive rate (score) of hMLH1 and hMSH2 expression in HCC was 48.7%(1.65?1.70) and 59.5%(2.30?1.96), respectively, which was obviously lower than that in the adjancent tumor tissues with 83.8%(3.30?1.37), and 86.5%(4.30?2.01), and in the normal liver tissues with 88.2%(3.88?1.98) and 82.3%(4.29?1.83), respectively(P
