Effects of Spironolactone on Vascular Remodeling After Angioplasty of Rabbit Iliac Artery
- VernacularTitle:螺内酯对兔髂动脉球囊损伤后血管重塑的影响
- Author:
Shuqin LIU
;
Jingbo KONG
;
Rongkai WANG
- Publication Type:Journal Article
- Keywords:
Rabbits;
Spironolactone;
Vascular remodeling;
Angioplasty;
Restenosis
- From:
Journal of Chinese Physician
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of spironolactone on vascular remodeling of injuried rabbit artery. Methods 20 male New Zealand rabbits were randomly divided into two groups. The rabbit models of iliac artery angioplasty were set up by BC. After injury, control group was fed with standard forage, and experimental group was fed with standard forage and spironolactone(20mg?kg~ -1?d~ -1). The rabbits were killed four weeks after injury. The injuried segments of iliac artery were removed, and processed for histological and morphological analysis by imumohistochemistry and TD 2000 analysis system of pathology image. Results AUIEM and AUEEM in the experimental group significantly increased as compared with the control group(P0.05). Conclusion Spironolactone could improve vascular remodeling after angioploasty of iliac artery in rabbits.
