The relationship between human papillomavirus infection and the carcinogenesis and pathological features of colorectal carcinoma
- VernacularTitle:人乳头瘤病毒与结直肠癌发生和病理特征的关系
- Author:
Kewei JIANG
;
Shan WANG
;
Ruyu DU
;
Yang KE
;
Yingjiang YE
;
Youzhi YU
;
Weigang FANG
;
Yi ZENG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Papillomavirus;
Polymerase chain reaction;
Hybridization in situ
- From:
Chinese Journal of General Surgery
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between HPV infection and human colorectal carcinogenesis. Methods Colorectal carcinoma specimens from 72 Chinese patients were studied. DNA extracted from colorectal tissue was screened for HPV L1 by polymerase chain reaction (PCR), HPV subtype 6,11, 16, and 18 were detected by PCR using specific primers and in situ hybridization using specific probe. Results Twenty-four specimens out of 72 (33%) colorectal cancer were HPV L1 positive. The normal colorectal mucosa was HPV L1 negative. The location, infiltration and metastasis of colorectal carcinoma were all significantly related with HPV infection. The predominant HPV subtype was HPV 16,which was found in 58% of all HPV-positive colorectal carcinoma. Conclusion The presence of HPV DNA suggests that HPV may be involved in the carcinogenesis of colorectal carcinoma. HPV infection is closely related with the malignant potential of colorectal cancer.
