Preparation Technique of Fluconazole for Injection and Its Stability Study
- VernacularTitle:注射用氟康唑的制备工艺及稳定性研究
- Author:
Guiying FU
;
Xiaohua GUO
;
Ying ZHAO
;
Jun YANG
;
Kun WU
- Publication Type:Journal Article
- Keywords:
Fluconazole for injection;
Preparation technique;
Content determination
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To select a technique for preparation of fluconazole for injection and to establish a method for determination of its content.METHODS:The formula was selected on the basis of pH value and species of solution adjuvant.The content was determined by HPLC.RESULTS:The preparation was stable when pH value was between6.5～8.5,and its clarity could be increased by propylene glycol.The detectable concentration of fluconazole showed a good linear correlation in the range of40～200?g/ml.The average recovery was100.37%,RSD=1.37%(n=3).CONCLUSION:The fluconazole for injection prepared by the present technique is stable in quality and the method for content determination is accurate and practicable.
