Determination of Metformin Hydrochloride in Compound Metformin Hydrochloride Tablets by UV-Spectrophotometry
- VernacularTitle:紫外分光光度法测定复方盐酸二甲双胍片中盐酸二甲双胍的含量
- Author:
Fang WU
;
Lianjian CHEN
;
Cheng LI
;
Ting LI
;
Fuxing HUANG
- Publication Type:Journal Article
- Keywords:
Compound metformin hydrochloride tablets;
UV-spectrophotometry;
Metformin hydrochloride;
Content de?termination
- From:
China Pharmacy
2001;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish UV-spectrophotometry method in the determination of metformin hydrochloride in compound metformin hydrochloride tablets.METHODS:The determination was carried out with water as the solvent under the detection wavelength of233nm.RESULTS:There was a good linear relationship between metformin hydrochloride and its absorbability(r=0.9999)within the concentration range of1～10?g/ml.The average recovery was99.3%with RSD at0.24%(n=9).CONCLUSION:The method is accurate,fast,convenient,and which can be used to determine the contents of metformin hydrochloride in compound metformin hydrochloride tablets directly without isolation.
