Expression of Fragile Histidine Triad Gene and its Association with Proliferation and Apoptosis of Tumor Cells in Cutaneous Malignant Melanoma
- VernacularTitle:恶性黑素瘤FHIT基因蛋白的表达与肿瘤细胞增殖、凋亡关系的研究
- Author:
Shenqiu LI
;
Chunmei ZHANG
;
Fen XIONG
- Publication Type:Journal Article
- Keywords:
FHIT gene;
Melanoma;
Proliferating cell nuclear antigen;
Apoptosis
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of fragile histid ine triad (FHIT)gene and its relationship with the proliferation and apoptosis of tumor cells in cutaneous malignant melanoma (CMM).Methods The expression o f FHIT gene and PCNA were detected by streptavidin peroxidase method with skin s pecimens taken from 57 primary cutaneous melanoma and 20 normal controls.Apopto sis of tumor cells was detected by terminal deoxynuclneotidyl transferase mediat ed dUTP nick end labeling (TUNEL).Results The expression level of FHIT protei n was significantly lower in CMM than that in the normal skin tissue (P
