CCR7~+CD8~+CD45RO~+ T Cells induced Differentiation of CD4~+T Cells to Th2 Cells in Active Systemic Lupus Erythematosus
- VernacularTitle:系统性红斑狼疮患者CCR7~+CD8~+CD45RO~+T细胞诱导CD4~+T细胞向Th2分化
- Author:
Lang CHEN
;
Chunchen WU
;
Yuling HE
;
Luokun XIE
;
Gang ZHOU
;
Jinquan TAN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,systemic;
CD8-positive T-lymphocytes;
CD4-positive T-lymphocytes;
Interleukin-4;
Interleukin-10;
Transforming gro wth factor beta;
Interferon typeⅡ
- From:
Chinese Journal of Dermatology
1994;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the functions of CCR7+CD8+CD45RO+ T cells on CD4+T cells in systemic lupus erythematosu(SLE).Methods The expres sion of cytokines in CD4+T cells was measured by flow cytometry,real-time qua ntitative reverse transcription polymerase chain reaction and Northern blotting.A chemotaxis assay was used to detect their functions.Results In the case of active SLE,CCR7+CD8+CD45RO+T cells could induce CD4+T cells to express high le vels of Th2-cytokine (IL-4),and low levels of Tr1-cytokines (IL-10 and TGF-?),than those in normal controls and inactive SLE (P
