Relationship between the concentration of fetal total bile acid and fetal adrenocortical dysfunction in intrahepatic cholestasis of pregnancy
- VernacularTitle:妊娠肝内胆汁淤积症胎儿总胆汁酸浓度与肾上腺皮质功能变化的关系
- Author:
Yiling DING
;
Xiafei FU
- Publication Type:Journal Article
- Keywords:
Intrahepatic cholestasis of pregnancy;
Total bile acid;
Fetal adrenal gland;
Cortisol;
Dehydroepiandrosterone-sulfate(DHEA-S)
- From:
Chinese Journal of Perinatal Medicine
1998;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association of fetal total bile acid (TBA) concentration with fetal adrenocortical dysfunction in intrahepatic cholestasis of pregnancy(ICP). Methods The concentration of TBA, cortisol and DHEA-S in the cord blood were measured in 20 fetuses with maternal ICP (ICP group) and 22 fetuses of normogravidas (control group) after elective cesarean section. The cord blood TBA concentration was investigated by enzyme method and the cord concentration of cortisol and DHEA-S by radioimmunoassay. Results The cord TBA concentration in ICP group was significantly higher than that of controls [(8.93?3.16)mmol/L vs (4.33?1.51)mmol/L, P0.05)]. The cord blood level of cortisol,DHEA-S and the ratio of DHEA-S over cortisol were correlated with the cord blood TBA concentration (r 1= 0.87,r 2=-0.88,r 3=-0.84,P
