Protection of maFGF against anoxia/reperfusion injury in isolated rat hearts
- VernacularTitle:改构型酸性成纤维细胞生长因子对离体大鼠缺氧再灌注心脏的保护作用
- Author:
Yan LI
;
Jing LI
;
Xiaokun LI
;
Daxiang LU
;
Renbin QI
;
Ying GUAN
;
Yongmei FU
- Publication Type:Journal Article
- Keywords:
Fibroblast growth factor 1;
Anoxia;
Myocardium reperfusion
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the protective effects and mechanisms of modified acidic fibroblast growth factor (maFGF) in anoxic reperfusion of rat hearts. METHODS: Using Langendorff apparatus, we established the model of anoxia/reperfusion of isolated hearts to compare the protective effects of maFGF and acidic fibroblast growth factor (aFGF). The changes of left ventricle development pressure (LVDP) and maximal rates of rise of ventricular pressure(dp/dt_~max ), maximal rates of decline of ventricular pressure (dp/dt_~min ) were determined, changes of LDH and MDA levels,SOD activity in efflux from coronary artery were also detected at different time point. RESULTS: Pretreatment with maFGF and aFGF produced a similar protective effect on myocardium during anoxia /reperfusion, including promoting obviously heart functional recovery after myocardial anoxia/reperfusion and reversing changes of LDH, MDA contents and SOD activity induced by anoxic/reperfusion. CONCLUSION: maFGF has a protective effect on anoxia/reperfusion heart, and the mechanism of this effect may be related to suppression of lipid peroxidation.
