Effects of anthocyanin on cholesterol efflux from mouse peritoneal macrophage foam cells
- VernacularTitle:花青素对小鼠巨噬泡沫细胞胆固醇外流的影响
- Author:
Min XIA
;
Mengjun HOU
;
Zhihong TANG
;
Huilian ZHU
;
Jing MA
;
Wenhua LING
- Publication Type:Journal Article
- Keywords:
Anthocyain;
Macrophages;
Cholesterol;
Genes, PPAR-?
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect of anthocyanin on cholesterol efflux and elucidate its possible molecular mechanism. METHODS: Mouse Peritoneal macrophages were loaded with 50 mg/L AcLDL to induce macrophage-derived foam cells. Cholesterol efflux from macrophage-derived foam cells induced by anthocyanin was determined by enzymatic methods. PPAR-? mRNA and protein expression in macrophage-derived foam cells was assayed by quantitative PCR and western blotting. RESULTS: Anthocyanins had the capacity of promoting cholesterol efflux from mouse peritoneal macrophage-derived foam cells and increased PPAR-? mRNA and protein expression. CONCLUSION: Anthocyain-induced cholesterol efflux may be related to its enhancing PPAR-? mRNA and protein expression.
