Effects of peroxisome proliferator-activated receptor ? activator rosiglitazone on myocardial ischemic-reperfusion injury in rats
- VernacularTitle:PPAR?激动剂罗格列酮对心肌缺血再灌注损伤的影响
- Author:
Dengfeng GENG
;
Wei WU
;
Dongmei JIN
;
Juan LEI
;
Jingfeng WANG
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferators ?;
Rosiglitazone;
Myocardial reperfusion injury;
Renin-angiotensin system
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of peroxisome proliferator-activated receptor ? (PPAR?) activator rosiglitazone on myocardial ischemic-reperfusion injury in rats. METHODS: Forty-two SD rats were randomly divided into three groups: sham group (n=14), I/R group (n=14) and I/R+rosiglitazone group (n=14). Myocardial infarct size was assessed by NBT staining. Plasma and myocardial angiotensin and aldosterone as well as plasma renin activity were detected by radioimmunoassay. RESULTS: Compared with I/R group, myocardial infarct size was reduced by 23.9% (P
