Preparation of CD40L-PLL-CpG ODN conjugated complex and its targeting B lymphocytes
- VernacularTitle:CD40L-PLL-CpG寡核苷酸交联复合物的制备及其对B淋巴细胞的靶向性
- Author:
Jianwei JIANG
;
Meizhen ZHENG
;
Huilan ZENG
;
Yaoying ZENG
;
Jingfang DI
;
Yuxia YAN
;
Meiyu WU
- Publication Type:Journal Article
- Keywords:
CD40 ligand;
Oligonucleotides;
Conjugated complex;
B-lymphocytes;
Targeting
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
98%), the peak level of uptake occurred earlier, intracellular fluorescence intensity maintained much more stable. Expressions of CD19+, CD22+, CD20+ increased significantly. A_~570 values of MNCs proliferation and IgG levels in supernatant were all higher. CONCLUSION: CD40 ligand-PLL carrier system may delivery CpG ODN targeting to B lymphocytes, enhancing its immunological efficiency.
