In vitro inhibitory effect of CD_8~+ cells from patients with aplastic anemia on normal CFU-Mk growth is blocked by cimetidine
- VernacularTitle:组胺H_2受体阻滞剂阻断再生障碍性贫血患者CD_8~+细胞抑制正常CFU-Mk生长的作用
- Author:
Ming LI
;
Mingchun WANG
;
Qiongli ZHANG
;
Xin DU
- Publication Type:Journal Article
- Keywords:
Anemia, aplastic;
CD_8~+ cells;
Hematopoietic stem cells;
Receptors, histamine H_2;
Cimetidine
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effect of CD_8+ cells from aplastic anemia (AA) patients and its histamine type II (H_2) receptors on the growth of normal CFU-Mk. METHODS: The effects of CD_8+ cells and/or cimetidine, on normal human CFU-Mk growth were studied by using CFU-Mk assay. RESULTS: The CD_8+ cells from the perpheral blood of AA patients significantly suppressed the growth of normal allogeneic CFU-Mk. This inhibitory effect was blocked by cimetidine at concentration of 1.0?10~-5 mol/L. 1.0?10~-5 mol/L cimitidine alone didn't inhibit the growth of normal CFU-Mk. CONCLUSION: H_2 receptor antagonist cimitidine abolishes the suppressive effect of AA patients CD_8+ cells on the growth of normal CFU-Mk.
