Effect of MCT on CYP7A1 gene expression and cholesterol metabolism in mice
- VernacularTitle:中链甘油三酯对小鼠胆固醇代谢和胆固醇7?-羟化酶表达的影响
- Author:
Yan LI
;
Jing MA
;
Pinghua HAN
;
Wenhua LING
- Publication Type:Journal Article
- Keywords:
Triglycerides;
Cholesterol;
Bile acids and salts;
Cholesterol 7 alpha-hydroxylase
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the effect and the corresponding mechanism of medium chain triglyceride (MCT) on CYP7A1 gene expression in mice. METHODS: C57BL/6J mice (15/group) were respectively received mash as AIN-93G formula (basic control BC), or 1% cholesterol supplemented AIN-93G formula (Chol), or 1% cholesterol and 14% long chain triglyceride (LCT) rich in myristic acid supplemented AIN-93G formula (Chol+LCT), or 1%cholesterol and 14% MCT (caprylic acid/capric acid: 3/1) supplemented AIN-93G formula (Chol+MCT) for 6 weeks. The change of serum total cholesterol (TC), the content of cholesterol in liver, the bile acid pool of mice and the expression of cholesterol 7-hydroxylase (CYP7A 1) gene were investigated. RESULTS: Compared to mice fed Chol diet, the mice fed Chol+MCT diet had the lower serum TC (P
