The diversity of structure and function of heparin sulfate proteoglycans via modification of some relative enzymes
- VernacularTitle:硫酸乙酰肝素糖蛋白的结构-功能多样性与相关修饰酶群作用
- Author:
Duyin JIANG
;
Xiaobing FU
;
Zhiyong SHENG
- Publication Type:Journal Article
- Keywords:
Heparin sulfate proteoglycan;
Basement membrane;
Extracellular matrix
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The cytokine-receptor- heparin sulfate functional complex combined by cytokines, cytokine receptors, and heparin sulfate chains formed by concatenation of heparin sulfate proteoglycans (HSPG), an important component of extracellular matrix and modified by some relative enzymes, can regulate the density of cytokine receptors and their intracellular signal transduction. This article focused on the regulatory function of this complex. Many morphological abnormalities and diseases occur when the complex is dysfunctional.
