Regulation of cytochrome P450 genes by liver-enriched transcription factors
- VernacularTitle:肝富集的转录因子与细胞色素P450基因的表达调控
- Author:
Jian ZHUGE
;
Yingnian YU
- Publication Type:Journal Article
- Keywords:
Cytochrome P450;
Liver-enriched transcription factors;
Hepatocyte nuclear factor;
Expression
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 (CYP) is a complex gene superfamily of proteins that metabolizes a myriad of endogenous and exogenous substrates. Liver-enriched transcription factors (LETF) play a role in the constitutive and tissue-specific expression of hepatic genes. In this review, six families of LETF that play a role in the tissue-specific, developmental, sexual and temporal regulation of CYP are discussed.
