Study on the Mechanism of Litchi Saponin in Improving Action of Insulin Resistance in Rats with Hyper-lipemia-Hepar Adiposum
- VernacularTitle:荔枝核皂苷改善高脂血症-脂肪肝大鼠胰岛素抵抗作用的机制研究
- Author:
Jiewen GUO
;
Xiaobing JIAN
;
Danlei WEI
;
Lianyi DAI
- Publication Type:Journal Article
- Keywords:
Litchi saponin;
Insulin resistance;
Hyperlipemia;
Hyperinsulinemia;
Tumor necrosis factor-?
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the mechanism of litchi saponin in impr oving action of insulin resistance(IR)in rats with hyperlipemia-hepar adiposum.METHODS:The hyperlipemia-hepar adiposum was used to establish IR model of rats,the effects of litchi saponin,roglitazone and gliclazide on the index of fasting serum glucose(FSG),total cholesterol(TC),triacylglycerol(TG),high density lipoprotein-cholesterol(HDL-C),tumor necrosis factor(TNF)-?,content of insulin,in?sulin sensitivity(ISI)and so on were observed in the model rats2hours after medication.RESULTS:Litchi saponin could sig?nificantly lower the level of FSG,TC,TG,contents of insulin and the concentration of TNF-?(P
