Study on Pharmacokinetics of Lung Targeted Tetrandrine Polylactic Acid Microspheres in Rabbits
- VernacularTitle:汉防己甲素肺靶向聚乳酸微球兔体内药动学的研究
- Author:
Guohua CHENG
;
Jiabo LUO
- Publication Type:Journal Article
- Keywords:
Tetrandrine;
Lung targeted microspheres;
Pharmacokinetics;
RP-HPLC
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To provide scientific evidence for the microsphere's m etabolism in vivo of lung targeted tetran?drine polylactic acid(TET-PLA)microspheres.METHODS:Blood was sampled from carotid artery after microspheres were injected into rabbit through auricular vein,the concentration of TET in plasma was determined by RP-HPLC method;The pharmacokinetic parameters were obtained by using3p87program.RESULTS:Concentration-time curves of TET micro?spheres were fitted to a2-compartment model with t 1/2? of(286.49?237.55)min and AUC of(810.33?287.49)(?g?min)/ml.CONCLUSION:TET-PLA microspheres show sustained release effects in rabbits.
