Preparation and Quality Control of the Compound Metronidazole Hollow Suppository
- VernacularTitle:复方甲硝唑中空栓的制备及质量控制
- Author:
Ying YAO
;
Tao WANG
;
Zhenqiang XU
;
Liqin DENG
- Publication Type:Journal Article
- Keywords:
Metronidazole;
Ofloxacin;
Hollow suppository;
Ultraviolet spectrophotometry;
Quality control
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To prepare and establish quality control for the compo und metronidazole hollow suppository.METHODS:The compound metronidazole hollow suppository was prepared with semisynthesis fatty acid glyceride as ground substance;The contents of metronidazole and ofloxacin were determined by dual-wave length K-ratio method and equivalent absorption dual-wave length method.RESULTS:The detecting concentration linear range of metronidazole and ofloxacin were6.0~18.0?g/ml and3.0~9.0?g/ml respectively,the average recovery were100.98%and99.56%(n=5)respectively,RSD were0.82%?0.80%respectively.CONCLUSION:This method is convenient,accurate and reproducible,which can be used for the quality control of compound metronidazole suppository.