Relationship between Plasma Endotoxin Levels and Administration of Antibiotics in Patients with Severe Traumatic Injury
- VernacularTitle:严重创伤患者血浆内毒素含量监测与抗菌药物应用的相关性研究
- Author:
Qi LUO
;
Fuxin WANG
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Plasma endotoxin;
Traumatic injury;
Kinetic turbidimetric assay
- From:
China Pharmacy
2001;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To discuss the relationship between the changes in pla sma endotoxin levels and use of antibiotics in patients with serious traumatic injury before and after operation.METHODS:The plasma bacterial endotoxin levels were dynamically detected by kinetic turbidimetric assay in20patients with severe traumatic injury used with different antibiotics before and after operation,at the same time the normal control group was established.RESULTS:Plasma endotoxin levels in patients with severe traumatic injury increased remarkably before and after operation,as compared with the normal control group(P0.05).CONCLUSION:Intestine-borne endotoxin induced in a stress condition can strengthen the pathological reaction of the body ,therefore dy?namic detection of plasma endotoxin can provide guidance for clinical therapy.
