Effect of the spleen on intestinal barrier function in rats with acute pancreatitis
- VernacularTitle:大鼠急性胰腺炎反应中脾脏对肠屏障功能的影响
- Author:
Zheng LU
;
Yanliang ZHU
;
Changlin HE
;
Jinxi LIU
- Publication Type:Journal Article
- Keywords:
Pancreatitis/physiopathol;
Spleen/physiopathol;
Intestinal Barrier Function;
Disease Models,Animal
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the spleen on the function of intestinal barrier during the course of acute pancreatitis in rats.Methods Rats were randomly divided into four groups: sham operation group; actue pancreatitis group; splenectomy group;splenectomy plus acute pancreatitis group.The serum levels of TNF-?,IL-1,IL-6 and IL-10 in each group were examined 24 hours after operation.Two days after operation ,the rate of bacterial translocation(BT) was determined and the terminal ileum was excised and examined by transmission electron microscopy to detect the injury of intestinal mucosa.Results The serum levels of TNF-?,IL-1?,IL-6 and IL-10 in splenectomy plus acute pancreatitis group were 3.06?3.61,16.46?5.52,19.90?6.89,6.94?3.93,and in acute pancreatitis group were 19.93?2.38, 42.79?4.31, 20.19?3.35, 39.28?12.69 respectively. The values of TNF-?, IL-1? and IL-10 were significantly lower in splenectomy plus acute pancreatitis group than those in acute pancreatitis group(P
