Effect of ectogenic lysolethcin choline on blood-brain barrier permeability in rats with acute pancreatitis
- VernacularTitle:外源性溶血卵磷脂对急性胰腺炎大鼠血脑屏障通透性的影响
- Author:
Xiaofeng LIU
;
Zhuyin QIAN
;
Yi MIAO
- Publication Type:Journal Article
- Keywords:
Pancreatitis/physiopathol;
Blood-Brain Barrier;
Lysorhospholipase
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of lysolecithin choline (LPC) on blood-brain barrier(BBB) permeability in rats with acute pancreatitis. Methods Acute pancreatitis rat model was produced and rats were randomly divided into:(1)Test group-AP, rats received LPC by tail vein injection; (2)control group I, AP rats were given normal saline by tail vein injection; (3)control group II, sham operation without AP, but LPC was given by tail vein injection.Horseradish peroxidase(HRP) was used as a tracer to determine BBB permeability 7~10 days later.Results The test group showed local extravascular effusion of HRP, indicating that BBB permeability was markedly increased,while both control groups showed no apparent increase of BBB permeability,which were statistically significant(P
