The protective effect of ischemic preconditioning on pancreas transplantation in rats
- VernacularTitle:缺血预处理对大鼠胰腺移植的保护作用
- Author:
Tingting HE
;
Xiaonan LIU
;
Weizhong WANG
;
Kaizong LI
;
Wenxian GUAN
;
Dongl CHEN
- Publication Type:Journal Article
- Keywords:
Pancreas Transplantation;
Ischemic Preconditioning;
Reperfusion Injury
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of ischemic preconditioning (IPC) on pancreas transplantation(PT) in rats. Methods Steptozozin-induced diabetic SD rats were randomly assigned to 2 groups: group I/R (ischemia/reperfusion), consisted of 30 diabetic rats which received PT; group IPC, consisted of 30 diabetic rats which received pancreas transplantation and IPC. Six rats in each group were randomly sacrificed at 2 days before PT, and 3 days and 7days after PT, to detect the level of blood sugar and amylase,and pancreatic sections were stained with HE simultaneously; 6 rats were used to observe various metabolic indexes , and other 6 rats were used to observe the rat survival rate. Results The rats of group IPC had a higher 1 month survival rate than group I/R (5/6 vs 3/6, P
