Immune-deficient dendritic cells can induce tolerance to transplantation of xenogenic islet cells
- VernacularTitle:免疫缺陷树突状细胞诱导异种胰岛细胞移植耐受
- Author:
Gang ZHAO
;
Fang WANG
;
Chunyou WANG
- Publication Type:Journal Article
- Keywords:
Islets Langerhans Transplantion;
Transplantion Tolerance;
Dendratic Cell
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether host derived immune-deficient dendritic cells (DC) were capable of inducing immunological tolerance to islet xenografts and to ascertain its mechanism. Methods Immune-deficient DC were obtained from marrow of BALB/C mice by inductive differentiation,and loaded with MHC antigen of Wistar rat. The loaded DC were injected into diabetic model mice through tail vein,and,7 days later, islet of Wistar or SD rats were implanted beneath the renal capsule. Survival time of grafts was monitored. Mixed lymphocyte culture and TH1/TH2 cytokine expression were observed. Results Compared to the untreated mice, the survival time of Wistar islets was significantly prolonged in the pretreated mice(P
