The effect of recombinant human endostatin combined with 5-Fluorouracil on the growth of xenografted gastric cancer in nude mouse
- VernacularTitle:重组人内皮抑素联合应用5氟脲嘧啶对胃癌裸鼠移植瘤的影响
- Author:
Tianbao WANG
;
Wenguang DONG
;
Zhaoting LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Endothelial growth factors;
Proliferating cell nuclear antigen;
Proto-oncogene proteins c-bcl-2
- From:
Chinese Journal of General Surgery
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective This experiment was to identify the influence of recombinant human endostatin (rhES) combined with 5-FU on the growth of a xenografted gastric cancer in nude mouse. Methods After the establishment of the model, mice were divided into 4 groups (six in each) receiving respectively, for consecutive 10 days: NS, 5-FU (10 mg/kg) intraperitoneally; rhES (2 mg/kg); and 5-FU + rhES. On 15th day tumor volume was measured. The expression of VEGF, bFGF, VEGF-C, PCNA, bcl-2 and apoptosis index (AI) were examined. The tumor inhibition rate(TIR) and tumor shrinking rate(TSR) were calculated. Results Tumor volume was (43?2) mm 3 in 5 FU+rhES group,(169?45) mm 3 in 5 FU group, (95?28) mm 3 in rhES group, (1057?114) mm 3 in control group ( P
