The Effect of Yinchenwulin Powder on the c-myc mRNA Expression of VSMC in Atherosclerosis Rats
- VernacularTitle:茵陈五苓散对动脉粥样硬化大鼠VSMC c-myc mRNA表达的影响
- Author:
Dongsheng WANG
;
Fangping CHEN
;
Zhaokai YUAN
- Publication Type:Journal Article
- Keywords:
Yinchenwulin powder;
Atherosclerosis;
Rat;
Vascular smooth muscle cell;
Gene expression
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of Yinchenwulin(YCWL) powder on the c-myc rnRNA expression in vascular smooth muscle cell (VSMC) of atherosclerosis(AS) rats. Methods 70 Wistar rats were randomly divided into four groups: normal, model, Gypenosides treatment and YCWL powder treatment groups. AS models of rats were set up by feeding with high fat diet for one month. One month after treatment the level of serum lipid and blood rheology were measured, the phathological change of aorta was observed by HE staining, the ultrastructure change of aorta was observed by transmission electronic microscope, and c-myc mRNA expression in VSMC was detected by RT-PCR. Results Compared with Gypenosides treatment, YCWL powder could obviously decreased the levels of serum TC,TG and LDL, increase serum HDL level, reduce plasma viscosity,whole blood mid-cut,hematocrit and platelet adhesion rate, maintain aorta tissue structure, and down-regulate c-myc mRNA expression. Conclusion YCWL powder has therapeutic effect for atherosclerosis by regulating c-myc mRNA expression.
