Experimental Study of Low Molecular Weight Heparin Therapy for Kidney Injury in Severe Acute Pancreatitis
- VernacularTitle:低分子量肝素治疗重症急性胰腺炎肾损伤的实验研究
- Author:
Fu QIU
;
Xinsheng LU
;
Yukun HUANG
- Publication Type:Journal Article
- Keywords:
Low molecular weight heparin;
Severe acute pancreatitis;
Kidney injury;
Nuclear factor kappa B
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of low molecular weight heparin (LMWH) on kidney injury in severe acute pancreatitis (SAP). Methods SD rats were randomly divided into 3 groups: Sham operation (S) group,SAP group, and LMWH treatment (LT) group. In LT group LMWH was administrated 4 hours after SAP model establishment. The levels of serum amylase, creatinine (Cr) and tumor necrosis factor alpha (TNF-?), renal morphological change, and the expression of p65 mRNA and protein in renal specimens were determined 24 hours after model establishment or LMWH treatment. Results The levels of serum amylase,Cr,TNF-? in SAP group were significantly higher than those in S group and LT group (all P0.05). The expression of p65 protein and mRNA of renal tissues in SAP group was significantly higher than that in S group and LT group (all P
