Expression of COX-2 in the Carcinogenesis of Gastric Epithelia and Its Correlation with Cell Apoptosis and Proliferation
- VernacularTitle:胃癌形成中COX-2的表达及其与细胞凋亡和增殖的关系
- Author:
Yuefang CAI
;
Mingliang ZHANG
;
Yueqin YAN
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Precancerous lesions;
Cyclooxygenase-2;
Apoptosis;
Proliferation
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of cyclooxygenase-2 (COX-2) in the gastric epithelial carcinogensis and its relation with cell apoptosis and proliferation. Methods 15 cases of normal gastric mucosa (NGM), 30 cases of intestinal metaplasia (IM), 30 cases of dysplasia (Dys) and 40 cases of gastric cancer (GC) were used in this study. The expressions of COX-2 and proliferating cell nuclear antigen (PCNA) were detected by immunohistochemical SABC method, and cell apoptosis was measured by TUNEL. Results The expression level of COX-2 gradually increased from NGM, IM, Dys to GC. The positive rate of COX-2 in GC was 67.5%, 13.3% in NGM, and 33.3% in IM. There was a significant difference in COX-2 expression between GC and IM, GC and NGM(P0.05). The expression of COX-2 in poorly differentiated cancer was markedly higher than that in well differentiated cancer (P
