The Expression of Interleukin 13 mRNA in Peripheral Blood Mononuclear Cells in Patients with Ulcerative Colitis
- VernacularTitle:溃疡性结肠炎患者外周血单个核细胞IL-13mRNA表达的研究
- Author:
Yu ZHOU
;
Wentao YE
;
Hao WANG
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Interleukin13(IL-13);
Peripheral blood mononuclear cells(PBMCs);
RT-PCR
- From:
Journal of Chinese Physician
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of interleukin 13(IL-13) mRNA in peripheral blood mononuclear cells (PBMCs) and its association with serum C-reaction protein(CRP) in patients with ulcerative colitis(UC). Methods IL-13 mRNA expression in PBMCs was detected by RT-PCR in patients with UC(21 cases of active UC and 10 cases of quiescent UC)and 20 healthy subjects. At the same time, the serum level of CRP was detected by ELISA. Results The expression level of IL-13 mRNA in PBMCs of patients with active UC was significantly lower than that in PBMCs of patients with quiescent UC and healthy subjects (6.45?1.23 vs 14.72?2.12 or 15.17?2.38,P0.05). The expression level of IL-13 mRNA in PBMCs of active UC patients was negative correlation with serum level of CRP (r=-0.589,P
