Empirical Study on the Effects of Different Dosage of Grassleaf Sweetflag Rhizome on Central Nervous System
- VernacularTitle:不同剂量石菖蒲对中枢神经系统影响的实验研究
- Author:
Qiduan WU
;
Yongqi FANG
;
Ling LI
;
Zhongsheng KUANG
;
Gang WEI
;
Shuangfeng LIN
;
Xiaobing LI
;
Shuying WANG
- Publication Type:Journal Article
- Keywords:
Grassleaf sweetflag rhizome;
Central nervous system;
Dosage;
Empirical study
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the effect of different dosage of grassleaf sweetflag rhizome on central nervous system.METHODS:The effects of different dosage of grassleaf sweetflag rhizome on the hours of sleep and hypoxia live time of mice were observed,and the effects of which on water contents of brain tissues,apoptosis,endothelin(ET),malonaldehyde(MDA),erythrocuprein(SOD),glutathione peroxidase(GSH-Px),etc.in rats with cerebral ischemia were observed as well.RESULTS:Compared with the control group,different dosage of grassleaf sweetflag rhizome could shorten the sleeping time of mice and prolong the live time of hypoxia mice;high dosage of grassleaf sweetflag rhizome could remarkably decrease the water content of brain tissue and MDA level and inhibit the apoptosis of brain tissue cells while increase the activity of SOD and GSH-Px.CONCLUSION:High dosage of grassleaf sweetflag rhizome has the strongest protective effects to central nervous system,the effects of middle and low dosage of grassleaf sweetflag rhizome are lower than that of the high dosage.
