To Optimize Formula for the Compound Naftifine Hydrochloride Cream by the Orthogonal Experimental

VernacularTitle:正交试验筛选复方盐酸萘替芬乳膏处方
Author: Kui LIU
Publication Type:Journal Article
Keywords: Compound naftifine hydrochloride cream; Naftifine; Ketoconazole; Orthogonal experimental design
From: China Pharmacy 2001;0(09):-
CountryChina
Language:Chinese
Abstract: OBJECTIVE:To optimize formula for the compound naftifine hydrochloride cream and to study the stability of its finished products.METHOD:The dosage of the hexadecanol,octadecanol,S-40and sodium dodecyl sulfate was taken as variable factor,the orthogonal experimental design method was adopted and L 9 (3 4 )table was chosen for the experiment.RE-SULTS:The optimized formula is composed of4%of hexadecanol,2%of octadecanol,6%of S-40and0.1%of sodium do-decyl sulfate,from which the finished products manufactured had good stability.CONCLUSION:The cream prepared from this optimized formula and method can meet the specification stated in Chinese Pharmacopoeia.