Simultaneous Determination of 2 Ingredients in Compound Diphenhydramine Liniment by GC
- VernacularTitle:气相色谱法同时测定复方盐酸苯海拉明搽剂中2组分的含量
- Author:
Yingshun JIN
- Publication Type:Journal Article
- Keywords:
Gas chromatography;
Liniment;
Camphor;
Menthol;
Content determination
- From:
China Pharmacy
2001;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To establish the method for simultaneous determination of camphor and menthol in compound diphenhydramine liniment.METHODS:The DB-WAX capillary column was used.The column temperature was increased by programming with the sample entrance and detector being at250℃.The carrier gas was nitrogen.The flow rate was1ml/min and shunting ratio was25∶1.N-octyl alcohol was used as internal standard.RESULTS:The determinable concentrations of camphor and menthol were in the linear range of0.1～1.2mg/ml(r=0.9998)and0.2～1.2mg/ml(r=0.9999)respective-ly.The average recoveries were98.78%and97.88%respectively.CONCLUSION:The established method is accurate,spe-cific and replicable,which can be applied to quality control of the liniment.
