Treatment of Condyloma Acuminata with 5% Imiquimod Cream: A Randomized Double-Blind, Placebo-Controlled, Multi-Center Clinical Tria

VernacularTitle:5%咪喹莫特乳膏治疗尖锐湿疣多中心、随机、双盲研究
Author: Kun CHEN ; Zaipei GUO ; Zhigang BI ; Baozhu LIN ; Xingping CHEN ; Baozhu CHANG ; Yizhi ZHANG ; Meihua ZHANG ; Fanqin ZENG ; Wen JIANG ; Heng GU
Publication Type:Journal Article
Keywords: Condylomata acuminata; Imiquimod; Randomized controlled trials
From: Chinese Journal of Dermatology 1994;0(05):-
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical efficacy and safety of 5% imiquimod cream in topical treatment of anogenital warts. Methods A randomized, double-blind, parallel placebo-controlled clinical study was conducted. Patients with anogenital warts were instructed to apply the test drug topically and then clean the drug with water 6 ~ 8 hours later, three times a week for 8 weeks. Patients whose warts cleared completely were followed up for one month to determine recurrence rates. Results Two hundred and thirty-one patients with anogenital warts were enrolled in this trial. One hundred and sixteen patients were randomly selected to receive 5% imiquimod cream; and the other receive placebo cream. For 2, 4, 6, 8 weeks, the cure rates were 8.41%, 30.84%, 49.53%, 61.68%, respectively in the study group, and 2.68%, 7.14%, 16.07%, 24.11%, respectively in the control group (P