Immunohistochemical Study on Bcl-2 and PCNA in Mixed Tumor of Skin
- VernacularTitle:皮肤混合瘤中bcl-2和增殖细胞核抗原的免疫组化研究
- Author:
Deyuan YOU
;
Yandong WANG
;
Haiyan YOU
- Publication Type:Journal Article
- Keywords:
Mixed tumor of skin;
Proto-oncogene proteins bcl-2;
Proliferating cell nuclear antigen
- From:
Chinese Journal of Dermatology
1994;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of bcl-2 and PCNA in mixed tumor of skin. Methods Bcl-2 and PCNA expression in 12 cases of mixed tumor of skin were studied using immunohistochemical S-P method and double-staining. Results Positive reactions of bcl-2 and PCNA were observed in all cases. PCNA staining was positive in tumor cells lining cystic and duct-like structures in tumor nests, but bcl-2 staining was positive in epitheloid tumor cells. Most tumor cells with bcl-2 were PCNA negative and vice versa. Conclusion Aberrant expression of bcl-2 and PCNA in mixed tumor of skin may play a role in tumorigenesis.
