Experimental study of tinnitus on electrophysiology
- VernacularTitle:耳鸣电生理学实验性研究
- Author:
Zhiwu HUANG
;
Ping CHEN
;
Zhanyuan WU
;
Zezhang TAO
- Publication Type:Journal Article
- Keywords:
Tinnitus;
Salicylates;
Electrophysiology
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To find the evidence of electrophysi ol ogic mechanisms associated with average spectrum of electrophysiological cochleo neural activity (ASECA), a measure of spontaneous auditory nerve activity altera tions. METHODS: The long-term salicylate treatment was used to establis h the available animal model of tinnitus, the ASECA was monitored, and the effec ts of various presented ipsilateral acoustic were investigated. RESULTS: (1) In the first treatment, ASECA decreased acutely dur ing several hours after salicylate administration. After several days (1 week an d 2 weeks) this decrease was reduced. (2) Over weeks of salicylate administratio n, the level of ASECA increased progressively, but at the end of treatment, acou stic tuning of ASECA showed a partially decreased sensitivity. (3) In control an imals, delivery of an ipsilateral noise reproduced the increase in the level of ASECA that was similar to the result observed in long-term salicylate-treated an imals. The noise (the white noise was 55-60 dB SPL) was of moderate level and it slightly elevated CAP thresholds at higher frequencies. CONCLUSION: In the long-term salicylate-treated animals, the ASE CA-1 kHz increased reflects strongly increased synchronized activity in the audi tory nerve.
