Mechanism by which activation of ?_1-adrenoceptor before is chemia controls myocardial apoptosis
- VernacularTitle:缺氧前激活?_1受体对心肌细胞凋亡的影响及机制
- Author:
Hong FANG
;
Yibai FENG
;
Ying FANG
- Publication Type:Journal Article
- Keywords:
Receptors, adrenergic, alpha-1;
Myocardium;
A poptosis
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the mechanism for biological effect of ? 1-adrenoceptors by inves tigating the molecular mechanism involving in the apoptotic processi on in myocardium. METHODS: The expressions of Bcl-2, Bax, cytochrome C, caspase-3 were determined by means of immunohistochemistry and molecular technique. RESULTS: Bcl-2 was increased but apoptosis, Bax, cytochrome C, caspase-3 were decreased when phenylephrine was used before ischemia. CONCLUSION: ? 1 -adrenoceptors may influence the expression of Bcl-2 ,change the permeabil ity of mitochondrion and adjust the expression of apoptotic protein to control apoptosis.
