Suppressive effect of Chuankezhi (CKZ) injection on murineal lergic contact dermatitis
- VernacularTitle:喘可治注射液抑制小鼠变应性接触性皮炎的实验研究
- Author:
Kaixuan XIONG
;
Yaoying ZENG
;
Xiaochang CAI
;
Tong WANG
;
Jingxian ZHAO
;
Min YI
- Publication Type:Journal Article
- Keywords:
Hypersensitivity, delayed;
Dermatitis, allerg ic contact;
Chuankezhi
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the suppressive effect of c hu ankezhi (CKZ) injection, a Chinese medicine, on murine allergic contact dermatit is (type IV hypersensitivity). METHODS: Mice were divided into 6 groups according to different medicine treatments: CKZ high, middle, low dose ( CKZⅠ,Ⅱ,Ⅲ) groups, dexamethasone(DEX), benadryl and saline groups. Murine alle rgic contact dermatitis was induced by intraperitoneal injection of 2, 4-dinitro fluorobenzene. Different medicines were administrated at 2 h before sensitizatio n on day 0 and day 1, day 2, 2 h before elicitation and 6 h after on day 5. The six experimental groups were compared according to left ear thickness difference (S1), left ear weight difference (S2), body weight difference (S3) and dermal i nflammatory infiltration cell number. RESULTS: Compared with saline group, the left ear swelling and d ermal inflammatory infiltration cell number were significantly reduced in CKZⅠ, Ⅱ,Ⅲ and DEX groups (P
