The relation between prolonged survival of skin allograft by chuan-ke-zhi and CD4~+CD25~+ regulatory Tcells
- VernacularTitle:喘可治延长小鼠异基因移植皮片存活时间与CD4~+CD25~+调节性T细胞相关性研究
- Author:
Youping WANG
;
Yaoying ZENG
;
Jingxian ZHAO
;
Li ZHAO
;
Feiyue XING
;
Jingfang DI
;
Xun JIANG
;
Haixian LI
- Publication Type:Journal Article
- Keywords:
Chuan-ke-zhi;
CD4+CD25+ regulatory T cell s;
Transplantation, skin;
Flow cytometry
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the relation between prolon ge d survival of skin allograft by chuan-ke-zhi (CKZ, drug of Chinese herbal) and C D4+CD25+ regulatory T cells (CD4+CD25+ Tr) in mice. METHODS: Skin allograft and isograft model in mice were establi shed and CKZ was administered by intraperitoneal injection. To observe its influ ence on survival of the graft, three color fluorescent staining together with fl ow cytometry was used to analyze the change of CD4+CD25+ Tr. RESULTS: The survival of skin allograft in CKZ group was signifi cantly prolonged compared to control group, (19.5?2.3) days and (10.2?2.2) days, respectively, P0.05). CONCLUSION: CKZ has an effect of prolonging the survival of skin allograft. Enhancement of CD4+CD25+ Tr might be one of the mechanisms under lying its immunosuppressive effect.
