Effect of breviscapine on the oxidative stress in the liver and kidney in diabetic rats
- VernacularTitle:灯盏花素对糖尿病大鼠肝、肾组织氧化应激的影响
- Author:
Min ZHAO
;
Yonggui WU
;
Hui LIN
;
Hao QIAN
;
Dian ZHOU
;
Li HAO
- Publication Type:Journal Article
- Keywords:
Diabetes, mellitus;
Rats;
Liver;
Kidney;
Oxid ative stress;
Breviscapine
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the effect of breviscapine on the oxidative stress in the liver and kidney in diabetic rats. METHODS: Diabetes was induced by injection of streptozotocin (ST Z). Rats were randomly divided into three groups: control group, model group, mo del group treated with breviscapine. 8 weeks after STZ injection, liver lesion w as evaluated using HE, oil red O staining and kideny lesion using PAS staining. Malondiadehyde (MDA) levels and antioxidant activities in liver and kidney tissu e were determined by spectrophotometric method. RESULTS: Light microscopy in HE staining showed that liver fatty score was significantly lower in the breviscapine group compared with model ani mals (0.55?0.43 vs 1.54?0.65, P
