Immunoisolation effect of xenografts of microencapsulated human chromaffin cells in rats
- VernacularTitle:微囊化人嗜铬细胞对大鼠异种移植的免疫隔离作用
- Author:
Jiheng CHEN
;
Maoyuan YANG
;
Jiyong LI
- Publication Type:Journal Article
- Keywords:
Chromaffin cells;
Transplantation,heterologous;
Immunity
- From:
Chinese Journal of Anesthesiology
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the immunoisolation effect of xenografts of microencapsulated human chromaffin cells (HCCs) .Methods HCCs were microencapsulated with APA microcapsules. Forty-eight SD rats were randomly divided into 3 groups ( n = 16 each) . HCCs (group I ) , empty APA microcapsules (group II ) and microencapsulated HCCs (group III ) were implanted into the anterior chamber of the eyes and the sole of the feet. Seven days after transplantation blood samples were collected for determination of serum IL-2, IgG and IgM concentration. The right eye-balls and left feet were obtained for microscopic examination. Results The serum IL-2, IgG and IgM concentrations were significantly lower in group II and group III than in group I ( P
