Relationship of oncogene survivin,p53 expression in breast cancer and its prognostic significance
- VernacularTitle:乳腺癌组织中survivin,p53蛋白的表达与预后的关系
- Author:
Jie MAO
;
Jian HAI
;
Hengping SHU
;
Lili TANG
;
Zhengtang SHEN
;
Yuhui WU
;
Huiyin OU
- Publication Type:Journal Article
- Keywords:
BREAST NEOPLASMS/pathol;
GENE,p53;
GENE,survivn;
LYNPHATIC METASTASIS;
PROGENSIS
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of oncogene survivin,p53 in breast cancer and its ~prognostic significance. Methods The expression of survivin,p53 in breast cancer tissues of 80 cases were detected by immunohistochemistry S-P method, and its correlation with axillary lymph node metastasis and ~5-year disease free survival (DFS) was analysed.Results In breast cancer tissues,survivin gene positive ~expression rate was 68.75%(55/80), p53 gene positive expression rate was 46.25%(37/80), and both had a positive correlation with axillary lymph node metastasis but negative correlation to 5 years DFS(P0.05);survivin and p53 genes expression have positive corrlation(P
