GAD and GADmRNA expressions in human gastric cancer
- VernacularTitle:GAD及GADmRNA在人胃癌组织中的表达
- Author:
Renmin ZHU
;
Sudi QIN
;
Fangyu WANG
;
Xiaoping HE
;
Wenan XU
;
Lin WANG
- Publication Type:Journal Article
- Keywords:
Glutamate decarboxylase;
Gastric cancer;
mRNA
- From:
Chinese Journal of Digestive Endoscopy
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of glutamate decarboxylase (GAD) in the pathogenesis of human gastric cancer. Methods Thirty patients with primary gastric cancers who were diagnosed and treated at our hospital were enrolled into the current study. Immunohistochemistry was carried out to check the ex-pression of GAD protein. Reverse transcription polymerase chain reaction ( RT-PCR) was performed to ex-amine the expression of GADmRNA. Then investigated the relationships among the sites of gastric cancer, depth of infiltration, and degree of differentiation, staging and lymphatic metastasis. Results Immunohisto-chemistry analysis showed that GAD expression decreased in gastric cancer tissues compared with that of ad-jacent normal tissue(P
