Blockade of intrathoracic lymphatic flow significantly ameliorates intestinal bacterial translocation in rats with obstructive jaundice
- VernacularTitle:阻断淋巴通道对梗阻性黄疸大鼠肠道细菌易位的影响
- Author:
Xinze ZHOU
;
Qinshen MAO
;
Yaohui NI
;
Ruixin CHEN
;
Xiu YU
;
Liping LU
- Publication Type:Journal Article
- Keywords:
Cholestasis;
Bacterial translocation;
Endotoxemia;
Thoracic duct
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of lymphatic flow impedement on intestinal bacterial translocation in rats with obstructive jaundice. Methods Murine obstructive jaundice model was established by ligating lower choledochus. Sixty rats were divided into three groups: sham-operative group (group A), obstructive jaundice group (group B), and obstructive jaundice with thoracic duct ligation group (group C). At post-op day 15 vena cava inferior blood? portal vein blood were drawn, and endotoxin, TNF-?, IL-6 were determined. Baterial culture of mesenteric lymph nodes and lung were measured with aseptic manipulation. The extreme intestinal lumen mucosa and lung were studied pathologically. Results Blood concentration of endotoxin increased in group B and C ( P
