Studies on hepatic carcinoma cell invasion in vitro through Rho/Rho kinase pathway
- VernacularTitle:Rho/Rho激酶对肝癌细胞体外侵袭转移作用的研究
- Author:
Desheng WANG
;
Kefeng DOU
;
Kaizong LI
;
Zhenshun SONG
;
Qingchuan ZHAO
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Neoplasm metastasis
- From:
Chinese Journal of General Surgery
1997;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of Rho/Rho kinase -associated cell migration of hepatic carcinoma cell line and inhibition of tumor cell invasion by Rho kinase inhibitor Y-27632. Methods Western blot was used to estimate the expression of Rho protein in the cells. After treatment of SMMC7721 cell with Y-27632, cell biological behaviors such as colony-forming efficiency, adhesiveness, cell motility, in vitro invasiveness, metastatic potential were observed. Results The ability of Y-27632 treated SMMC7721 cells to invade the reconstituted basement membrane decreased significantly ( P
